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Microscope Products
Microscope Products
We develop high-tech precision microscopes for the analysis of microstructures with the user, for the user. In our product portfolio you will find microscopes for life science including biotechnology and medicine as well as for research and development of raw materials and industrial quality assurance.
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Microscope Products
High-tech precision microscopes for the analysis of microstructures. Find microscope solutions for life science, medical, R&D and industrial quality assurance.
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The Award-Winning Inspection Microscope
The Emspira 3, which integrates comparison, measurement, and documentation sharing into a single system, has won a prestigious Red Dot Award.
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Take a look at all our upcoming congresses, exhibitions, webinars, and workshops and join us at one of our next events!
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Read our latest articles
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments.
Explore Alzheimer's Spatial Proteome with Big Data
Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options, new investigative strategies are crucial. The Cell DIVE multiplexed imaging solution allows examination of Alzheimer's brain tissue, potentially uncovering new research avenues. Here, we showcase the Cell DIVE image viewer, enabling users to access the full Alzheimer's multiplexed dataset directly in their browser.
Guide to Microscopy in Cancer Research
Cancer is a complex and heterogeneous disease caused by cells deficient in growth regulation. Genetic and epigenetic changes in one or a group of cells disrupt normal function and result in autonomous, uncontrolled cell growth and proliferation.
A Guide to Model Organisms in Research
A model organism is a species used by researchers to study specific biological processes. They have similar genetic characteristics to humans and are commonly used in research areas such as genetics, developmental biology, and neuroscience. Model organisms are typically chosen for their easy maintenance and reproduction in a laboratory setting, short generation cycles, or the capacity to generate mutants to study certain traits or diseases.
Dive into Pancreatic Cancer Research with Big Data
Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC), examining molecular and spatial determinants of tumor aggression in metabolism, apoptosis, and immunity. Access the full Cell DIVE dataset in your browser to delve deeper into these findings.
Uncover the Hidden Complexity of Colon Cancer with Big Data
Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like immunotherapies. Spatial biology approaches, such as multiplexed imaging with Cell DIVE, can provide crucial insights for developing novel treatments. Access the full Cell DIVE dataset in your browser to explore these findings further through the Minerva image viewer.
Introduction to 21 CFR Part 11 for Electronic Records of Cell Culture
This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories. It is intended for professionals in the biotechnology and pharmaceutical industries who are responsible for ensuring agreement with 21 CFR part 11 for electronic records and electronic signatures. A digital microscope approach, e.g. with Mateo FL, offers the advantage of more consistent and efficient electronic documentation of cell-culture results compared to a paper-based method.
A Guide to Darkfield Microscopes
A darkfield microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.
A Guide to Phase Contrast
A phase contrast light microscope offers a way to view the structures of many types of biological specimens in greater contrast without the need of stains.
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Designing the Future with Novel and Scalable Stem Cell Culture
Visionary biotech start-up Uncommon Bio is tackling one of the world’s biggest health challenges: food sustainability. In this webinar, Stem Cell Scientist Samuel East shows how they make stem cell culture media for cellular agriculture safe and economically viable. See how they achieved a 1000x reduction in media costs and developed animal free, food safe iPSC culture media.
From Bench to Beam: A Complete Correlative Cryo Light Microscopy Workflow
In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).
How to Study Gene Regulatory Networks in Embryonic Development
Join Dr. Andrea Boni by attending this on-demand webinar to explore how light-sheet microscopy revolutionizes developmental biology. This advanced imaging technique allows for high-speed, volumetric live imaging of 3D samples with minimal phototoxicity. Learn through user examples how light-sheet microscopy is enhancing our understanding of intestinal and brain organoid development and dive into the technology behind the Viventis Deep microscope from Leica Microsystems and its application in long-term imaging.
Cutting-Edge Imaging Techniques for GPCR Signaling
With this webinar on-demand enhance your pharmacological research with our webinar on GPCR signaling and explore cutting-edge imaging techniques that aim to understand how GPCR signaling translates into cellular and physiological responses. Discover leading research that's expanding what we know about these critical pathways to find new avenues for drug discovery.
Revealing Neuronal Migration’s Molecular Secrets
Different approaches can be used to investigate neuronal migration to their niche in the developing brain. In this webinar, experts from The University of Oxford present the microscopy tools and assays they use to elucidate the molecular mechanisms of neuronal migration to functional layers of the cortex during neurodevelopment. Understanding these processes will lead to a better understanding of healthy brain development and potentially better treatments for neurodevelopmental disorders.
How Efficient is your 3D Organoid Imaging and Analysis Workflow?
Organoid models have transformed life science research but optimizing image analysis protocols remains a key challenge. This webinar explores a streamlined workflow for organoid research, starting with real-time 3D cell culture checks. This is followed by high-speed, high-resolution 3D imaging to generate crisp images and cleaner data for accurate AI-based segmentation and quantification of parameters such as growth rate, cell migration and 3D cellular interactions – enabling deeper insights.
Improve Your Ultramicrotomy Workflow with Automated Sectioning
Discover advanced digital ultramicrotomy tools for fast and accurate automated sectioning. Learn about autoalignment, and efficient sample trimming leveraging 3D µCT data. See application examples that advance EM sample preparation workflows. Watch now to enhance your lab's precision and efficiency.
How do Cells Talk to Each Other During Neurodevelopment?
Professor Silvia Capello presents her group’s research on cellular crosstalk in neurodevelopmental disorders, using models such as cerebral organoids and assembloids.
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Fluorescence Lifetime-based Imaging Gallery
Confocal microscopy relies on the effective excitation of fluorescence probes and the efficient collection of photons emitted from the fluorescence process. One aspect of fluorescence is the emission wavelength (spectral characteristics of a fluorophore). Another one, very powerful albeit less explored, is the fluorescence lifetime (the time a fluorophore stays in the excited state). Information based on fluorescence lifetime adds an additional dimension to confocal experiments, revealing information about the fluorophore microenvironment and enabling multiplex of spectrally overlapping species.
Physiology Image Gallery
Physiology is about the processes and functions within a living organism. Research in physiology focuses on the activities and functions of an organism’s organs, tissues, or cells, including the physical and chemical phenomena involved. Here we show you images related to physiology using different samples as examples.
Live Cell Imaging Gallery
Live cell microscopy techniques are fundamental to get a better understanding of cellular and molecular function. Today, widefield microscopy is the most common technique used to visualize cell dynamics and development over long times. Confocal microscopy is also a key tool to generate 3D images of structures and study highly dynamic cellular processes at high spatial and temporal resolution, keeping the specimen in a close to native state.
Super-Resolution Microscopy Image Gallery
Due to the diffraction limit of light, traditional confocal microscopy cannot resolve structures below ~240 nm. Super-resolution microscopy techniques, such as STED, PALM or STORM or some deconvolution processing methods, are used when enhanced resolution is needed to study structures and molecular events below the diffraction limit scale.
Tissue Image Gallery
Visual analysis of animal and human tissues is critical to understand complex diseases such as cancer or neurodegeneration. From basic immunohistochemistry to intravital imaging, confocal microscopy and advanced modalities can provide an understanding of cells, biomolecules and their interactions within their environment.
Neuroscience Images
Neuroscience commonly uses microscopy to study the nervous system’s function and understand neurodegenerative diseases.
Multicolor Image Gallery
Fluorescence multicolor microscopy, which is one aspect of multiplex imaging, allows for the observation and analysis of multiple elements within the same sample – each tagged with a different fluorescent dye – and the same experiment. This results in efficient experiments but also in more reliable and meaningful results to understand complex processes within cells and tissues.
This gallery shows images from specimens tagged with multiple fluorescent probes obtained with THUNDER and the STELLARIS platform.
Cancer Research Image Gallery
Fluorescence microscopy allows the study of changes occurring in tissue and cells during cancer development and progression. Techniques such as live cell imaging are critical to understand cancer progression and metastasis.
