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| Name | Borderline tumor of the right ovary. Specimen |
| Video Uploader | Video From Dr. Andreas Kavallaris |
| Upload Date | This Video Uploaded At 18-07-2022 13:15:07 |
| Video Discription | Borderline ovarian tumors (BOT) represent a heterogeneous group of noninvasive tumors of uncertain malignant potential with characteristic histology. Borderline ovarian tumors comprise about 15%–20% of all epithelial ovarian malignancies with an incidence of 1.8–4.8 per 100,000 women per year. BOTs differ significantly from ovarian carcinomas with regard to percentile distribution of tumor histotypes, lower FIGO stage, excellent overall prognosis, younger age distribution, higher infertility rate, and a lower frequency of BRCA mutations. Borderline tumors have been identified in all epithelial subtypes, including endometrioid, clear cell, Brenner (transitional cell) and mixed epithelial tumors. Serous (53.3%) and mucinous histologies (42.5%) are most common; the data are derived from a review of 5,807 patients provided by du Bois et al.. Borderline ovarian tumors are generally characterized by increased epithelial proliferation accompanied by nuclear atypias (usually mild to moderate) and mildly increased mitotic activity. Stromal invasion, however, is not displayed in this tumor entity. Almost 30% of patients with BOTs are asymptomatic; approximately 50%–60% of patients complain about nonspecific symptoms (abdominal pain or abdominal distension) and 10% complain of bleeding abnormalities. Most BOTs are detected by ultrasound. To establish a complete FIGO staging, a combination of laparoscopic intraoperative exploration of the entire abdominal cavity should be conducted, with peritoneal washings, omentectomy, multiple peritoneal biopsies, and complete resection of all macroscopic suspected lesions. For resection of the primary tumor, bilateral salpingo-oophorectomy in combination with hysterectomy ( in cases of non fertility sparing) is recommended. Lymphadenectomy is not indicated because the recurrence and survival rates for patients with positive or negative lymph nodes were similar . Optimal staging allows a correct pathological diagnosis to be obtained based on the entire tumor tissue and to define a group with a higher risk of recurrency. |
| Category | Science & Technology |
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